Histological study #11987/2017
The submitted samples affected large areas of oral mucosa included epidermis and dermis.
The epidermis has an increase in the number of layers (hyperplasia of acanthocytes) and showed multifocally a complete loss of the epidermis layer (ulcer). There is an inflammatory infiltrate adjacent to the ulcerated zone consisting of neutrophils, and a small amount of lymphocytes. Multifocally, there is extravasation of erythrocytes from the vessels (hemorrhage).
In the deep dermis, there is a proliferation of neoplastic odontogenic epithelium have peripheral palisading with reverse polarity of the nuclei and prominent intercellular bridges centrally typical of stellate reticulum. Cord-forming cells were cubic to polygonal, with sparse and eosinophilic cytoplasm (ameloblasts). The nuclei are large, ovoid, and polarized in the apical region. In addition, these cells exhibit anisocariosis. The nucleoli are magenta, prominent, and occasionally multiple. The cells forming the central zone (stellate reticulum) are fusiform with intercellular deposition of basophilic material (myxedema). The stroma is sparse and composed by fibroblasts, mature collagen fibers and neovascularization.