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Histological study #23678/2017

Histological study #23678/2017
Reference: 23678-2017
Date: 21/11/2017
Staining: Hematoxylin-eosin

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The oral mucosa is the mucous membrane covered by stratified squamous epithelium and an underlying connective tissue named lamina propria. The superficial epithelium displayed a multifocal well differentiated hyperplastic epithelial cells adopted a characteristic cords and nests, occasionally showed bridges between them in the connective tissue of papilar dermis. Along the basement membrane of the oral epithelium there is a separation of the layers by the deposition of a transparent substance (edema). There is a focal (erosions) and complete loss of the epidermis with basal membrane affected (ulcer).

There is cellular debris (necrosis) and an inflammatory infiltrate composed by neutrophils that surround the ulcerated area. There is extravasation of red blood cells from the vessels multifocally (hemorrhage).

In the superficial dermis, diffusely and densely periadnexal, there is an inflammatory infiltrate composed by lymphocytes and plasma cells. In the deeper lamina propria there is a proliferation of scarcely cellular tissue composed by collagen fibers arranged in parallel (mature collagen) and a small number of mature fibroblasts scattered among the collagen fibers.

Histologically, inflammatory fibrous hyperplasia is made up of a mass of hyperplastic connective tissue with dilated blood vessels, usually with chronic inflammatory cells such as lymphocytes and plasma cells, but it can also be made up of solid connective tissue with minimum to no inflammatory cells, the latter called fibrous hyperplasia. The surface epithelium ranges from normal to acanthotic, ulcerated, keratotic or a combination of two or more of these features.